Sentence examples for mice with multiple from inspiring English sources
Zhou, J. et al. One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering.
Previous studies in mice with multiple gestational exposures to perfluorooctanoic acid (PFOA) demonstrate numerous dose dependent growth and developmental effects which appeared to worsen if offspring exposed in utero nursed from PFOA-exposed dams.
In contrast, Jaenisch and his colleagues, including MIT researcher Feng Zhang (a 2013 member of our list of 35 innovators under 35), reported last spring that CRISPR had allowed them to create a strain of mice with multiple mutations in three weeks.
To accomplish this, the team engineered a strain of mice with multiple copies of another gene that produces high doses of a certain enzyme.
The generation of transgenic mice with multiple conditional oncogenes is a tractable preclinical platform to define the combination of oncogenic targets most likely to be effective in the treatment of cancer.
As the authors suggest, further analysis in mice with multiple ENTPD gene deletions may be informative.
Representative coronal slices for unenhanced CT (a), contrast-enhanced SA-PET/CT (b and c), and necropsy photograph of a mouse with multiple abdominal lesions and hemorrhagic ascites (d).
Representative coronal slices for 18F-FDG SA-PET/CT (a) and contrast-enhanced CT (b) of a mouse with multiple abdominal lesions.
Histological examination of kidneys from these mice shows the development of renal carcinoma in all mice, often with multiple foci (Fig 3B).
Indeed, 14 days after treatment, nine of eleven PBS-treated mice had extensive lipid-associated droplets in the corpus callosum and only four of nineteen mice treated with multiple rhGas6 doses had low or moderate Oil-Red-O positive staining.
Another study (28) reported enhanced survival (average lifespan: 120 days) in Twitcher mice treated with multiple AAV.rh10.GALC injections (one intrathecal, two systemic and six intracerebral), a protocol that is feasible in mice but has limited potential for clinical translation, due to safety concerns.
