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C7-hypomorphic mice with moderately affected paws received losartan for 4 days.
More recently, a combination of phytocannabinoids called Sativex was tested in SOD1-G93A mice with moderately positive results [ 55].
A recent study in mice with moderately overexpression of Sirt1 reports prevention in age-related diseases, but without effects in lifespan [ 5].
In contrast, the other group acted as TP53-WT mice with moderately to severely increased Scr which was seen in both TP53 and ERCC1 WT groups in our study [ 14].
On the other hand, transgenic mice with moderately increased expression of SUR2A also acquire resistance to metabolic stress, which was explained by increase in numbers of sarcolemmal KATP channels and earlier channel activation in response to metabolic stress [2].
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The mean fluorescence intensity of FasL staining was not significantly different on CD5+ B cells from severely arthritic mice compared with moderately, mildly, or nonarthritic mice.
VILI was induced by ventilating mice for 6 hours with moderately injurious tidal volumes of 12 ml/kg.
The increase in step cycle duration in V1 IN-ablated mice is moderately correlated with flexor phase duration (aTA = 0.46).
However, we did measure adrenal size and found that compared with control mice, LKO mice had moderately but significantly enlarged (∼18%) glands, with HSD1KO adrenals even more so (∼45%) (Fig. 2B), indicative of chronic stimulation of the adrenal gland.
2-way ANOVA indicates a significant (P<0.05) overall effect of genotype on non-fasting plasma triglyceride levels, with both young and adult ctsk−/− mice showing moderately and not significantly reduced levels.
This is consistent with moderately enhanced positive selection of HY cells to the CD8+ T-cell lineage in female C2HY mice, as more of the Tet+ cells have differentiated to SP8.
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