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Labeling at 85°C showed comparable results in A431 tumor xenografted mice with minor differences regarding blood clearance, tumor and liver uptake but clear improvement as compared to 89Zr-DFO-ZEGFR:2377, labeled at room temperature, which was confirmed by MicroPET-CT imaging.
Two of 8 NVP-treated female mice with minor liver necrosis had ALT values of 286 and 80 U/L.
Most studies use variations of the original nude mouse model, incorporating deepithelialized, diced human abnormal scar tissue in the subcutaneous pockets on the back or thorax of nude, athymic mice, with minor alterations.
The sharp rise in urinary protein:creatinine ratio observed in γ3 +/+ from 18 to 21 weeks and in +/- mice from 21 to 26 weeks was due in part to reduced creatinine excretion, whereas the sustained glomerular filtration in -/- mice (with minor glomerulosclerosis, see below) supported a more gradual increase in the urinary protein:creatinine ratio.
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Primary mouse hepatocytes were isolated from 8- to 12-week-old mice as described, with minor changes (Guidotti et al., 2003).
In contrast, stathmin-null mice are viable with minor axonopathies and loss of innate fear response.
The genetic background of the resulting mice is C57BL/6, with minor polymorphic contributions from the ES cells (33).
All samples were successfully re-passaged in NOD/SCID mice, a model with minor clonal selection in ALL [ 12].
Rib and sternum chondrocytes were isolated from three six-week-old wild-type and three Frzb -/- mice, as described with minor modifications [ 23].
The combined treatment with 5 U g−1 CRIS and 10 mg kg−1 MSO (three times a week for 3 weeks) was well tolerated by athymic nude mice, with only a minor, although significant, decrease in body weight and no significant alterations in liver and spleen weights.
Local retinal detachment was induced in the right eye of adult mice, as previously reported with minor modification [41].
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