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Commensurate with decreased plasma homocysteine and alanine aminotransferase levels, targeted hepatic expression of DYRK1A in mice with intermediate hyperhomocysteinemia resulted in elevated plasma paraoxonase-1 and lecithin cholesterol acyltransferase activities and apolipoprotein A–I levels.
Aside from hepatic steatosis, hepatic inflammation and fibrosis were seen in mice with intermediate levels of core protein.
In mice with intermediate core expression (experiment II), 194 genes were differentially expressed (120 were upregulated and 74 were downregulated) compared to the STM liver.
However, the liver from mice with intermediate HCV core protein expression exhibited an inflammatory infiltrate that was concentrated around hepatocytes displaying the core protein.
The synergistic effect of hepatic inflammation and core-related oxidative stress may lead to high MDA levels in these transgenic mice with intermediate core protein expression.
This was recently confirmed in a study showing that mice presenting with a low tumor burden had a significantly higher complete response rate and a significant longer survival than mice with intermediate or high tumor burden.
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Kindling-induced granule cell axon sprouting as measured by the Timm stain was also attenuated in homozygous null mutants compared with +/+ mice, with an intermediate effect in +/- mice.
Our results revealed that both microSPECT/CT and microPET/CT with 111In- or 64Cu-DOTA-trastuzumab Fab fragments were able to image s.c. human tumor xenografts in mice with low, intermediate, or high HER2 expression.
In parallel, we tested the hypothesis that severity of underlying neurodegenerative pathology would predispose to acute cognitive deficits using mice with none, intermediate, or severe neurodegenerative pathology upon challenging them with systemic inflammation or vehicle control (Table 1).
We demonstrate that neutrophils play a role in limiting disease severity following infection of mice with stains of intermediate (HKx31; H3N2) and high virulence (PR8; H1N1) whereas they are not critical in controlling infection with avirulent BJx109.
Overall the luciferase expression was lowest in the brain, with intermediate mice displaying higher luciferase expression than susceptible mice, and highest in the lungs with no statistical differences between the clusters.
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