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FA also caused severely impaired kidney function in MCP-maintained mice, with increases in serum creatinine and BUN comparable to those given normal drinking water.
It was reported that targeted c-Myc deletion in the intestinal epithelium reduced the tumor number of Apc heterozygotic (ApcMin/+) mice with increases in apoptosis (Ignatenko et al., 2006).
Frequency analysis showed abnormal distribution of thymic subpopulations in caDGK mice, with increases in DN, ISP (TCRloHSAmed/hi) and CD8 SP cells, and a notable decrease in the percentage of DP cells.
Most importantly, MIRT1 and MIRT2 were, like in the derivation group, the most up-regulated lncRNAs in MI mice, with increases of 9-fold (P < 0.001) and 16-fold (P < 0.001), respectively.Third, 21 additional mice were enrolled in a time-course analysis.
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Scientists, using "gene therapy" to increase the levels of a single enzyme, recently created a strain of mice with increased physical abilities.
Data presented here further suggests that CORT-mediated changes in neurogenesis are required for behavioral effects, as mice with increased neurogenesis do not display CORT-induced behavioral effects.
Exposure to MPs also induced responses to oxidative stress pathways in mice with increased GSH-Px and SOD and decreased CAT.
Aged mice, with increased GluN2B subunit expression, exhibited improved long-term spatial memory, comparable to young mice.
Total femur bone volume, length, cross-sectional volume, and cortical volume and thickness were increased in mice with increased body mass, independent of rAAV treatment.
We show that chronic CORT has anxiogenic and depressive effects in a subset of behavioral tests, the elevated plus maze and the tail suspension test, which are prevented in mice with increased adult hippocampal neurogenesis (Figure 4).
In addition, hippocampal slices from aged mice with increased GluN2B subunit expression exhibited enhanced NMDA receptor-mediated excitatory post-synaptic potentials (EPSP).
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