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Fig. 5 Therapeutic effects in the immunocompetent BALB/c mice with highly aggressive tumors elicited by ST8-mediated secretion of Endostatin. a Potent treatment of large established tumors with ST8/pSEndo.
Alternatively, cleaved caspase 9 protein content begins to increase in symptomatic G93A mice, with highly expressed levels in end stage mice [88].
The strongly elevated inflammatory host response and the associated severe lung pathology observed in DBA/2J mice in this study are very similar to the response to infection of resistant BALB/c and C57BL/6J mice with highly pathogenic viruses.
Neutrophils are recruited to the respiratory tract following influenza virus infections of humans and mice [1] and large numbers infiltrate the airways following infection of mice with highly pathogenic viruses such as the reconstructed 1918 H1N1 virus and strains of H5N1 [3], [3].
In fact, recently established that the experimental infection of BALB/c mice with highly purified preparations of RSV A, at a dose of 107 PFU, induces a severe inflammatory response in lung tissue as early as 24 h after intranasal inoculation [39].
As mentioned above, our Pparg knockout assessment also included mice with highly expressed PTGDS transgenes.
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In addition viral loads were higher in mice infected with highly pathogenic viruses [52], findings that correlate with those in human patients [5].
C5a had also been found to increase in BALF of mice infected with highly pathogenic avian influenza H5N1 but not following seasonal IAV infection.
In mice inoculated with highly metastatic breast and lung cancer cell lines, treatment with an anti-PTHrP antibody, reduced both tumour burden and osteoclastic bone resorption (Guise et al, 1996; Iguchi et al, 1996).
Belardelli et al. [ 10] described that combined treatment with IL-1 beta and IL-2 produced a synergistic antitumor effect: 60% of mice injected with highly metastasized Friend Leukemia Cells survived.
For example, among mice with a highly aggressive type of cancer, 20% of those in which the cancer had fully spread, and 40% with a more limited spread, were completely cured after fasting in conjunction with chemotherapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com