Sentence examples for mice with genetically from inspiring English sources
Recent studies using mice with genetically engineered gap junction protein connexin (Cx) genes have provided evidence that reduced gap-junctional coupling in ventricular cardiomyocytes predisposes to ventricular arrhythmia.
In myelin-deficient Shiverer mice with genetically dysmyelinated axons, our DSG apparatus recordings revealed a multi-peak C-wave without preceding faster components.
To determine whether these receptors spark sickness behavior, Prinz and colleagues compared normal mice with genetically modified animals that lack the receptors.
In a virtuoso display of cutting-edge techniques, a team combined cloning, embryonic stem cells, and gene therapy to treat immune-deficient mice with genetically tailored stem cells.
The role of FcγRs in the initiation of autoantibody production, immune complex clearance, and SLE manifestations (e.g., nephritis) are discussed primarily in the context of murine models of disease as mice with genetically engineered modification of FcγRs expression have served as important tools in this area.
We have put these ideas into practice in two recent studies in which we generated enhanced cytotoxic T lymphocyte (CTL) responses, while retaining robust humoral responses, to wild-type viral proteins by immunizing mice with genetically modified forms of HIV-1 Env, Gag and Pol delivered in the form of plasmid DNA expression vectors.
The abundant proteoglycan, aggrecan, is resorbed from growth plate cartilage during endochondral bone ossification, yet mice with genetically-ablated aggrecan-degrading activity have no defects in bone formation.
Activating mutations of K-ras are the earliest consistently detected abnormality in the development of pancreatic cancer, and pancreatic cancers that spontaneously develop in mice with genetically-modified K-ras show similar features to those seen in patients [ 2].
He had created a super-mouse with genetically modified, pumped-up muscles.
Implantation of a female BDF1 mouse with genetically distinct (C57 and Agoutie) embryos produced highly similar GTM profiles (c. 95% concordance) between mother and offspring, regardless of offspring strain, which was also reflected in urinary metabolite profiles.
However, mice generated with genetically modified cDNA notoriously lack the essential intronic regions that regulate the temporal and spatial expression of the gene.
