Finally, we tested the therapeutic efficacy of crossreactive antibody fusions in mice with established arthritis.
GUDCA was further identified as an intestinal FXR antagonist that improved various metabolic endpoints in mice with established obesity.
Following the timeline depicted in the schema, mice with established systemic A20HA tumors were divided into two groups.
Kalled, S.L., Cutler, A.H., Datta, S.K. & Thomas, D.W. Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: Preservation of kidney function.
Sampson, J. H. et al. EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.
Combining T-cell costimulation with systemic VSV-cDNA treatment, long-term cures of mice with established i.c.
Moreover, administration of the IL-18 Adv to mice with established AHR greatly reduced AHR and IL-4 production and increased IFN-gamma production.
"When we blocked this signal in mice with established human leukemia, the cancer cells were more easily removed by the body's natural defenses," Majeti said.
In vivo efficacy was demonstrated in mice with established ovarian, breast, and pancreatic tumor xenografts, all of which express αvβ6 at intermediate to high levels.
As shown in Fig. 1 schema, mice with established systemic HA-expressing A20 lymphoma (A20HA) were either untreated or treated with CTX followed by adoptive transfer of naïve HA-specific CD4+ T cells.
For example, in mice with established orthotopic rhabdomyosarcoma tumors, treatment with a TLR9 agonist plus topotecan resulted in an improvement in survival rate (41 versus 22% for topotecan alone, P=0.09) (Weigel et al., 2003).
