Sentence examples for mice with developmental from inspiring English sources

Mice lacking SIRT1 survive when outbred but yield smaller, sterile mice with developmental defects [ 10, 11].

When the floxed Wls allele is excised by Wnt1-Cre, the resulting mice exhibit a phenotype similar to the Wnt1 null mice, with developmental abnormalities in the midbrain and hindbrain [ 104].

The prepubertal uterotrophic assay has been shown to be influenced by exposure to estrogen during fetal neonatal development in mice, with developmental exposure to low doses of estrogen increasing uterine responsiveness to estrogen (Newbold et al. 2004).

Thus, interference with mammary gland development in mice with developmental exposure seems to occur at low exposures; benchmark dose calculations using a variety of models showed that a 10% BMR corresponded to a serum-based BMDL for PFOA of 23 25 μg/L (or ng/mL) [ 12, 17].

A predicted MYB binding site was identified in intron 1 of ZEB1, the site which is mutated in mice with multiple developmental malformations, some of which were suggested to be related to dysfunctional EMT or MET [ 20].

Cui et al. recover a mouse mutant with developmental defects similar to those seen in humans with MKS, including polycystic kidneys and laterality defects.

In contrast to the apparent normal development of most p53 null mice, with only sporadic developmental defects, severe gastrulation defects have been observed in p53 deficient Xenopus embryos [19].

Interestingly, ligand-independent responses for VEGFR3 are consistent with developmental mouse phenotypes: deletion of VEGF-C and VEGF-D does not affect the development and maturation of blood vessels during mice development, while deletion of VEGFR3 does (Haiko et al., 2008).

The removal of exon IIIb in the mature transcript results in mice with a multitude of developmental defects in a variety of organ systems during embryonic development including lung, thymus, salivary gland, and kidney (De Moerlooze et al., 2000).

Indeed, expression of FLK1, VCAM1, and TBX4, which are mesoderm-associated genes with developmental roles in mouse extraembryonic mesoderm, was FGF independent and was observed in KRT7+ sorted cells.

Dph1 is also essential to mouse development as the Ovca1−/− mice die during embryonic development and at birth with developmental delay and defects in multiple organ systems.