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Mice with diabetes showed more severe plaque burden on aortic arteries and less smooth muscle cells but larger senescent cell ratio in plaque compared with mice with control diets.
While pretreatment of mice with control Lactobacillus (La-EV) provided slight protective benefits, La-IFN-β increased sensitivity to DSS.
We first compared the gene expression profiles of salivary gland tissues in melanoma-bearing mice with control mice and identified a list of 46 significantly up-regulated TFs (fold change>2 and P<0.05) (Table S1).
As a control condition, we selected 9 month-old WT mice with control diet.
Similarly, motor activity in folate-deficient mice was not significantly different from mice with control diet.
We therefore fed ob/ob mice with control or MCD diet for 5 weeks.
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Similarly, active zones were fewer in ACTA1- Ctnnb1−/− mice and ACTA1- Ctnnb1−/−::LSL- Ctnnb1∆TAD mice, compared with control mice, ACTA1- Ctnnb1−/−::LSL- Ctnnb1 mice, and ACTA1- Ctnnb1−/−::LSL- Ctnnb1TV-AA mice.
The withdrawal latency for the hotplate test over the first 60 minutes of testing was significantly faster in LG mice and HG mice, compared with control mice.
To compare engraftment of human cells in these mice with controls that died at two weeks, other experiments were performed where mice that received PBMC with iTreg or nTregs were also sacrificed at 14 days.
However, to assess the motor learning and behavior we compared the Ms2Yah mice with controls, using the rotarod and treadmill paradigms.
However, transcriptome analysis of both KIKI and KIKO mice revealed significant transcriptional modifications in these mice compared with control mice (Coppola et al., 2009).
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