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As noted above (Fig. 5d), DMBA-treated mice exposed to HFD over their life course had increased vascularity compared with mice with continuous LFD exposure.
Previous reports also provided promising results with complete reversal of diabetes (6/11 mice) in obese mice with continuous administration of FTY720 [ 107].
None of the diTDP-43WT mice (n = 16) showed reduced spontaneous activity, weight loss, or poor grooming, which were the phenotypes observed in 70%% of 5a iTDP-43WT mice with continuous hTDP-43 expression.
Given the lack of nuclear ERα protein but the presence of diffuse cytoplasmic ERα in the EO771-derived tumours and in 4T1.2 tumours, we determined whether their growth was impacted by administration of the ERα antagonist tamoxifen to the mice, with continuous treatment beginning on the day of tumour-cell inoculation.
We chose this duration of expression because 70%% of 5a iTDP-43WT mice with continuous expression of hTDP-43 are moribund and must be euthanized by postnatal day 24; therefore, both groups of mice expressed the transgene for approximately the same length of time.
This lung/tracheal mesenchyme-specific pattern of Cre induction by the Tbx4-rtTA transgene persisted to the end of gestation, since no mGFP was detected in organs other than the lung and trachea of the triple transgenic mice with continuous Dox induction from E6.5 to E18.5.
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We have previously shown a delay of death by lymphoma in SJL/J mice irradiated with continuous very low doses of ionizing radiation.
We investigated population and epigenetic effects on offspring after exposure to an environmental estrogen through treating mice with a continuous pre- and post-natal diet high in phytoestrogens.
While, the liver sinusoids in the As III -exposed mice become defenestrAs III -exposednuous endotheliumicembecome(Fig. 1B).
Direct comparison of plasma concentrations of C57BL6/J and SJL mice (Fig 12B) with continuous oral administration in the drinking water showed equivalent bioavailability and inversion of R-flurbiprofen in these strains and equivalent circadian rhythms, which are caused by the circadian rhythms of drinking behavior.
(B) TEM micrograph of sinusoid in arsenic treated mice, which show defenestration with continuous endothelium.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com