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The mice will develop tumors, just as the men did, and will receive the same treatments as the men.
Other cages hold animals genetically destined to get colon or prostate cancers, while yet other mice will develop neurological impairments of a kind associated with Alzheimer's disease.
Most NOD mice will develop severe insulitis by 10 weeks of age, and, in our experiments, a small percentage (<10%) of mice develop overt hyperglycemia by 12 weeks of age [1].
Both cohorts of mice will develop tumors approximately within 3 4 months of age and up to 6 months.
In the homozygous model, approximately 40 to 50% of humanized mice will develop arthritis (mediated by human TNFα), which can be treated clinically using TNF blockers.
E-cadherin knockout mice will develop spontaneous liver cancer and the loss will promote chemical induced (with diethylnitrosamine) liver cancer with strong expression of stem cell marker CD44 and EMT marker vimentin [ 116].
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So if you have a gene that you suspect might cause cancer, but you're not sure, you can introduce it into a mouse, and perhaps that mouse will develop cancer".
We have previously shown that the C57BL/6J (B6) mouse will develop obesity and diabetes if raised on a high-fat diet.
We have previously demonstrated that the C57BL/6J (B/6J) mouse will develop severe obesity, hyperglycemia, and hyperinsulinemia if weaned onto a high-fat, high-sucrose (HH) diet.
If embryonic stem cells are grafted into an adult mouse, they will develop into a type of tumour called a teratoma, which contains a variety of differentiated tissue types.
Because a number of CFA-treated NOD mice will eventually develop diabetes and the mice that are going to develop diabetes will do so by 30 weeks of age, we analyzed Sick and Non-Sick NOD mice that were >30 weeks of age.
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