Deficits occurred predominantly in female h-apoE4 mice, which support the hypothesis that humans carrying h-apoE4, especially women, have impaired spatial memory compared to those carrying h-apoE3.
The present results suggest stronger learning impairments in Dp71-null mice than in mdx mice, which supports the hypothesis that Dp71 loss has a major role in the genesis of cognitive deficits in DMD.
Previous studies showed that treatment with CXCR4 antagonists inhibited breast cancer metastasis to bone and lung [53], [54] and decreased bone destruction due to myeloma bone metastases [55] in mice, which supports our results.
The quantification shown in Figure 5C demonstrates that Mgmt −/− and DKO mice exhibit upon AOM treatment a dramatically higher level of apoptotic cells per crypt than the WT and Aag −/− mice, which supports the hypothesis noted above.
Betel-leaf aqueous extract failed to induce any tumour in the treated mice, which supports an earlier report of the lack of any carcinogenic principle in betel leaf, an essential constituent of betel quid.
The DNA binding activity of NF-κB is greatly increased in the diaphragm of pre-necrotic 15 and 18 day old mdx mice [27], which supports the interpretation that NF-κB activity is involved in the upregulation of these subunits.
In a recent publication Ohnishi et al. revealed that a transgenic expression of H. pylori CagA induces gastrointestinal neoplasms in mouse [23] which supports our in vivo-data.
We implemented a statistical model on simple but very unusual principles and tested it on Human and Mouse genomes, which supports the emerging new model of eukaryotic gene regulation.
ATP-synthesis-coupled-proton transports were highly expressed at the 4-cell stage in normal pig embryos, the 8-cell stage in pig SCNT embryos, and the 2-cell stage in mouse embryos, which supports the previous findings that ZGA events occur at these stages (Additional file 2: Figure S4C).
Increased content of SCFA and lower caloric output have been found in feces of mice treated with antibiotics, despite similar caloric intake as the non-treated mice [ 152], which support previous suggestions of an increased energy harvest leading to obesity [ 51].
