Sentence examples for mice which results from inspiring English sources

MTs also have important roles in copper homeostasis, evidenced by the crossing of a mouse model of Menkes disease (a copper efflux disease) with MT-1/2 knockout mice, which results in embryonic lethality [18].

Deletion of BHMT in mice, which results in greatly increased plasma Hcy and hepatic betaine, renders these animals susceptible to fatty liver and hepatocellular carcinomas [48].

This cell line was generated by inoculation of FV complex into mice, which results in an EPO receptor-dependent proliferation signal in erythroid precursor cells.

The oscillatory expression of NAMPT is abolished in clock/clock mice, which results in drastically reduced levels of NAD+ in MEFs derived from these mice.

These mice also have shorter limbs and axial skeleton and a thinner growth plate in cartilage than wild-type mice, which results in a slightly shorter body length and smaller body weight [ 84, 85].

In the current study, we have identified a novel ENU-induced Amelx mutation in M100888 mice which results in a marked dental phenotype and corresponds to similar reported mutations in human AI.

We lesioned the adrenal glands of mice, which resulted in decreased serum concentration of corticosterone (Fig. 6a,b).

To determine the effect of these AONs in dystrophic muscles, we performed intramuscular injections of ALK5 AONs in mdx mice, which resulted in a decrease in expression of fibrosis-related genes and upregulation of Myog expression compared to control AON-injected muscles.

Importantly, total brain weight was unaffected in Eps8KO mice, which resulted in an increase of its fractional contribution to body weight, in older mice (Fig. 1D).

This is further supported by the systemic administration of antibodies to LFA-1 in NOD mice, which resulted in inhibition of infiltration of the lachrymal glands [18].

Here we show that a first-in-class inhibitor of nuclear import, cSN50 peptide, affords in vivo islet protection following a 2-day course of intense treatment in NOD mice, which resulted in a diabetes-free state for one year without apparent toxicity.