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Finally, to better define the molecular anatomy of diabetic nephropathy, we analyzed the altered gene expression patterns of glomerular endothelial cells in db/db mutant mice, which represent a useful model of this disease.
CD4+6.5+CD25− cells from dtg mice, which represent the majority of the FoxP3− population, can be considered as T conventional (Tconv) cells, because they are capable of proliferating and secreting IFNγ in response to various peptide doses and, in contrast to their CD25+ counterparts, do not suppress proliferation of 6.5+CD25− cells from stg mice (Fig. 1B).
Conversely, Spp1 has been reported to be upregulated in spinal hyperostosis of twy mice, which represent another Enpp1 allele (Aiba et al., 2009).
In one experiment, mice, which represent a novel environment, were simultaneously inoculated with two E. coli strains that differed only in mutation rate (Giraud et al. 2001).
High levels of miR-375 are found in the pancreatic islet of ob/ob mice (which represent a model of obesity, insulin resistance, and T2DM), and in patients with T2DM.
AKO mice which represent a rodent model of human neutral lipid storage disease with myopathy (NLSDM) [8] suffer from severe cardiac dysfunction due to ectopic triglyceride accumulation in the heart finally leading to premature death of the animals [1].
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The majority of these CP genes followed the p8 expression pattern in WT mice, which represents the unchanged-downregulated expression pattern.
We examined renal endothelial cells from the embryo and from the adult glomerulus, cortex and medulla compartments, as well as the glomerular endothelial cells of the db/db mutant mouse, which represents a model for human diabetic nephropathy.
In summary, we defined the gene expression profiles of the endothelial cells of the kidney during development, in distinct adult compartments, and in the glomeruli of the db/db mouse, which represents an important animal model for human diabetic nephropathy.
Ubiquitous expression of the Agouti protein was exhibited by yellow mouse, which represents an antagonist of the hypothalamic MC4 receptor.
In particular, this array covers 1281 mouse miRNAs, which represent the 88.6% of the mouse miRNAs listed in miRBase 19.
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