The H2p protein, which renders mice nonsusceptible to CIA, differs from H2q only by four amino acids in the peptide binding groove, and changing these to the corresponding amino acids in the H2q sequence makes the H2p mice susceptible to CIA [ 70].
To further investigate the role of cFLIP in this context, we used mice that exhibit a hepatocellular-specific deletion of cFLIP, which renders these mice susceptible to liver injury from apoptosis-inducing ligands.
The uPA-SCID mouse model uses immunosuppressed mice transplanted with human hepatocytes, which renders them susceptible to HCV infection (Mercer et al., 2001).
Although a minor splicing functional defect can be tolerated by mice which have a shorter life span, it may render an accumulative effect on retinal degeneration in humans.
Deletion of BHMT in mice, which results in greatly increased plasma Hcy and hepatic betaine, renders these animals susceptible to fatty liver and hepatocellular carcinomas [48].
In concordance with this observation, New Zealand Black mice, which suffer from mild lupus, also develop severe disease when rendered deficient in TNF [ 10].
The treatment of STAT6 KO mice, which develop CAMs and are highly resistant to infection, with an iNOS inhibitor in vivo rendered these mice susceptible to T. crassiceps infection [ 52].
They have been tested on mice, which are also vertebrates.
"The study subjects were mice, which are herbivores.
Then, they took tissue from the diseased mice and injected it into other mice, which also got the same disease.
But when the mice, which the psychologists whimsically referred to as "dancing mice," experienced too much stress, their performance tanked.
