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Genetically modified mice which produced too much Klf15 and those which produced none at all both had an increased risk of developing deadly disturbances in cardiac rhythm.
Additionally, functionality of the soy-mSEB as a vaccine antigen was demonstrated using mice which produced anti-SEB titers in blood serum after vaccination with soy-mSEB.
For the PN2 cell line, two mice produced macrometastases, greater than 1 mm in diameter, and the remaining seven mice, which produced lesions in the lung, were classified as micrometastases, as above (Table 2).
Subsequently, Zhang et al (36) transfected short-term cultured germline stem cells from neonatal and adult mice expressing GFP and transferred these into chemotherapy-pretreated recipient mice, which produced transgenic F1 and F2 offspring.
To observe its laxative effect, the plant extract was administered orally to healthy mice, which produced a dose-dependent laxation at 100 and 300 mg/kg, similar to carbachol (1 mg/kg).
A recent success in developing an animal model for Bartonella induced disease was the inoculation of the human pathogen B. henselae into C57BL/6 and BALB/c mice, which produced lymphadenopathy of some duration [ 22].
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In addition, the growth of the mutant was significantly restored in macrophages of iNOS knockout mice which produce a limited oxidative burst [2].
One µl of PrPSc aggregates purified from RML-inoculated C57BL/6 mice (which produce non-3F4 tagged PrPSc) was directly mixed (1∶200) with Tg WT-E1) brain homogenaTg WT-E1oaded into 0.2-ml PCR tubrain
We have also found that the level of a salt-extractable amphiphilic monomeric form of AChE is increased in the brains of transgenic mice which produce the human β-amyloid protein [50], and in the brain and CSF of rats which received intra-cerebroventricular injections of β-amyloid peptides [51].
This was confirmed in Fat-1 transgenic mice, which produce ω3-PUFAs.
To evaluate the in vivo requirement for nBMP2, we generated nBmp2NLStm targeted mutant mice, which produce nBMP2 that cannot translocate to the nucleus.
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