We also observed that the percentage of non-keratinocytic cells (mainly melanocytes) was higher in preparations of keratinocytes from knockout mice, which could potentially generate oxidative stress, influencing the growth of keratinocytes.
Altogether, we found SIRT6 has an integral role in IGF-1 signaling in the fat tissues of male mice, which could potentially explain the longevity seen in male mice overexpressing SIRT6.
Skin picking is also common among laboratory mice, which may develop potentially fatal ulcerative dermatitis, skin lesions, caused by excessive grooming.
However, the ability to produce sufficient virus exclusively using deer mice may present a logistical hurdle, which potentially may be surmounted by growing SVN in deer mouse cells.
More than 20,000 markers distinguished B6 mice from DBA/2 J and C3H/HeJ, which potentially contaminated the Tg EC-tTA) and Tg EC-tTA1) B6 congenic strands.
We identified two pairs of opposite strand overlapping coding loci in human and mouse, which could potentially serve as antisense with respect to each other: PAX3 and CCDS140 is one pair, and ZHX3 and PLCG1 the other.
The model predicts a previously unseen potentially dangerous elevation in blood pHe resulting from bicarbonate therapy in mice, which is confirmed by our in vivo experiments.
We used a floxed vector to establish conditional HSP60 transgenic mice, which allows studies on inducible and organ-targeted HSP60 expression in adult mice and is potentially useful in pursuing essential questions related to HSP60 in vivo.
This finding is supported by a recent study using hepatocytes isolated from 12-month-old mice which suggests that loss of Casp2 results in accelerated age-dependent changes to mitochondrial ROS production, potentially through altered complex III activity.
Health departments were provided with a list of facilities that had purchased these mice, educational resources about LCMV, and an algorithm to determine whether potentially infected mice remained at these purchasing facilities resulting from the presence, comingling, or breeding of these mice, which would maintain LCMV among the mouse population.
