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Indeed, we observed a profound increase in B220-positive cells in bleomycin-challenged gp130 757F mice, which persisted for 30 days (Supporting Information Fig S5B and C).
In open field and hole cross tests, ETAS significantly (p < 0.001) increased the movements of mice which persisted throughout the study period.
However, by 3 weeks of age, a significant reduction in size and weight was noted in the Ccnd1 KI/KI mice, which persisted over a period of 8 weeks and was independent of gender (Fig 2C).
Even at relatively low doses, Johansson et al. (2008) found developmental neurotoxic effects, including changes in spontaneous behavior and habituation ability, associated with PFOA and PFOS exposure in mice, which persisted into adulthood.
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This is consistent with the effects on the synaptic plasticity and cognitive functions of Ts65Dn mice, a model of Down syndrome, which persisted for a few months after similar treatment with GABAA receptor antagonists [23].
In these studies, all mice developed jaundice by 7 days, which persisted and became associated with poor weight gain until the time of death by 14 days after RRV challenge, as described previously [ 8, 12].
Beginning at 1 week, the XRT-WT mice showed a significantly greater increase in macrophages, which persisted throughout the period of observation (XRT-WT vs. XRT-TG, at 1, 3, 10, and 14 weeks, p < 0.05).
In mice, conjugate was found to have a higher plasma level, which persisted for a long time, and thus provided very effective passive targeting.
By contrast, Nrf2−/− mice demonstrated severely reduced bone mass at 3 weeks of age, which persisted through 12 weeks of age.
Compared to vehicle-injected mice, AβO-injected mice exhibited early activation of IKKβ in the hypothalamus (Fig 4D, 4 h after i.c.v. injection), which persisted for 7 days after i.c.v.
And when implants were placed in mice modified to have human immune systems, their bodies didn't reject the material, which persisted for up to 3 months.
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