Sentence examples for mice which mimic from inspiring English sources

We recently demonstrated that TNALP-deficient (Akp2−/−) mice, which mimic the phenotype of the severe infantile form of HPP, can be treated by intravenous injection of a recombinant adeno-associated virus (rAAV) expressing bone-targeted TNALP with deca-aspartates at the C-terminus (TNALP-D10) driven by the tissue-nonspecific CAG promoter.

Thus, we investigated here the therapeutic efficacy of DMF in R6/2 and YAC128 HD transgenic mice which mimic many aspects of HD and are characterized by an enhanced generation of free radicals in neurons.

These immunity patterns governing resistance or susceptibility to the fungus have been extensively demonstrated in murine models of infection, especially those comparing the course of the mycosis in A/Sn and B/10.A inbred mice, which mimic the polarized clinical forms of the human pcm [19].

The potential applicability of HDAC inhibitors for SMA therapy was confirmed in transgenic mice which mimic SMA-like features.

Previously, we reported that in the brain of Cln1 −/− mice, which mimic INCL, and in postmortem brain tissues from INCL patients, increased oxidative stress is readily detectable.

Moreover, DMF treatment leads to an increase in Nrf2 staining in neuronal subpopulations relevant for motor functions, concomitant with elevated Nrf2 immunoreactivity in R6/2 mice, which mimic many aspects of HD.

Similarly, administration of ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), has been shown to result in significantly reduced bacillary load and increased survival of C3HeB/Fej mice, which mimics the granulomatous response of human TB [55].

Menzies1-1 (strain 1) and Menzies1-2 (strain 2) were avirulent in mice, which mimicked their non-invasiveness in humans.

We found that in vivo depletion of TLR4 ligands, by all four methods, induced severe mortality in irradiated C57BL/10 mice, which mimicked TLR4−/− mice.

Saporta et al. (2012) recently reported in Brain the development of an Mpz R98C 'knock-in' mouse which mimics a form of CMT type 1B (CMT1B).

We show that increased SM levels in neurons of acid sphingomyelinase knock out mice (ASMko), which mimic Niemann Pick disease type A (NPA), result in reduced spine number and size and low levels of filamentous actin.