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There are fewer corpora lutea in the βERKO mice, which likely accounts for the observation that these mice are subfertile [7].
Furthermore, TSA decreased the expression of atrogenes in skeletal muscles of SMA model mice, which likely contributed to the motor behavior improvements observed following treatment (16, 17).
Matrix metalloproteinase (MMP -2 and MMP -2andivity were dramatically increased in UV-irradiated EP2 null SKH-1 mice, which likely contributed to the enhactivityC invasion [ 46].
Based on findings summarized herein, we now conclude that the WOE is sufficient to establish the MOA in mice, which likely involves the key events described in Figure 2.
To our surprise, the hypertrophic EAT in db/db mice, which likely contains a large number of differentiated adipocytes, expressed a decreased level of PPARγ mRNA compared to that observed in the smaller EAT in WT mice, presumably due to the greater extent of methylation of the PPARγ promoter in the EAT of db/db mice.
Since we quantified total axonal growth of RA mechanoreceptors by measuring CFP+ pixel number in the dorsal spinal cord, CFP+ axons/dendrites of these precocious RET+ dorsal spinal cord neurons are also included in the quantification of Gfrα1 null mice, which likely accounts for the increased dorsal spinal cord CFP+ pixels.
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Correlations between wasting and lung expression of TNF-α, CCL3, and CXCL2 were different (i.e., positive, negative, or insignificant) depending on the selected group of mice, findings which likely mirrored the dual role for these cytokines in TB protection/TB pathology.
Indeed, 3 passages were necessary to reach a degree of virulence comparable to that of vCJD agent in these mice (13 ), which likely reflects progressive adaptation of the agent to its new host.
Similarly, cognitive stimulation and physical activity have differential effects in neurogenesis and memory in AD mice, which are likely due to differences in animal models and EE conditions.
These results suggest that ER stress is similarly induced in tgWT and tgMT mice, which is likely the result of overexpression of the transgenic proteins.
Enhanced proliferation in multiple tissues and elevated levels of pro-inflammatory cytokines are profound features of homozygous Δ122p53 mice, which very likely contribute to the tumor phenotype.
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