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CD8 RTEs efficiently populated the gut of lymphotoxin-alpha-deficient mice, which lack lymphoid organs.
PON1 knockout (PON1−/−) mice, which lack PON1, represent a highly sensitive mouse model for toxicity associated with exposure to CPF or CPO.
Allergen-induced AHR, however, develops in beta(2 -microglobulin (beta(2 -microglobulin lack classical iNKT cells, suggesting that in some situations iNKT cells may betaispensable for the development of AHR.
In addition, human xenografts are transplanted into athymic nude mice, which lack an intact immune system.
The researchers saw the same effects in so-called germ-free mice, which lack gut bacteria.
β-Catenin-deficient mice, which lack the ability to activate canonical Wnt signaling, exhibited impaired hematopoietic stem cell regeneration and bone marrow recovery after radiation.
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Neutrophil levels do not significantly change with LPS administration in TLR4−/− mice, which lack TLR4 expression on both parenchymal cells and bone marrow-derived cells.
In contrast, Trp73 knockout mice (which lack all p73 isoforms) exhibit multiple developmental defects but no tumor predisposition [13].
Thyroid hormone treatment of hypothyroid Pax8 knockout mice, which lack thyroid follicular cells, had a very limited global effect on brain transcripts.
Naïve MHC class II-deficient mice, which lack conventional CD4+ T but have NKT cells, showed exaggerated baseline AHR and, when challenged with alpha-GalactosylCeramide, demonstrated even greater AHR.
RESULTS: TCR beta-/ mice, which lack all T cells except gamma delta T cells, routinely displayed higher levels of antibody than fully T cell-deficient mice.
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