Sentence examples for mice which indicates from inspiring English sources

Moreover, using immunostaining of PCNA to mark cell proliferation in pancreatic sections from KKAy mice, we demonstrated that long-term HBK001 treatment increased PCNA staining in islets of KKAy mice which indicates that HBK001 may induce regeneration of islet cells (Supplementary Fig. 2G).

MOG-specific T cells generated from WT mice induced less severe EAE in cPLA2alpha-/ mice compared with cPLA2alpha+/- mice, which indicates that cPLA2alpha plays a role in the effector phase of EAE.

Furthermore, we also observed an increased metastasis (one case of BM infiltration and one case of spleen infiltration) in ATM−/− Gadd45a−/− mice, which indicates that Gadd45a deletion increases the degree of malignancy of lymphoma in ATM−/− mice (Fig. 5D).

We have previously shown that GNPs are capable of inducing an antibody response in mice, which indicates that factors other than cytotoxicity may be involved and complicates in vivo application of GNPs [16].

Buckbinder et al. demonstrated an increase in alkaline phosphatase activity and increased bone mineralization in bone marrow cultures from Pyk2−/− mice, which indicates that Pyk2 may be involved in the regulation of differentiating pre-osteoblasts [30].

After T cell receptor activation, thymocytes isolated from Thy-1 null mice have increased SFK activity and cell proliferation when compared with thymocytes collected from wild-type mice, which indicates that Thy-1 inhibits T cell receptor-induced SFK activation and proliferation of thymocytes [4].

The strongest support for this cancer stem cell model comes from transplantation assays in immunodeficient mice, which indicate that human acute myeloid leukemia (AML) is driven by self-renewing leukemic stem cells (LSCs).

Taken together, our results demonstrated the higher GCL and GPx activities in female mice, which indicated their crucial roles in regulating the resistance of liver injury induced by hepatotoxins in female.

Two and four months after transplantation, the percentage of donor-derived T-cells and B-cells in PB and BM of ATM−/− and ATM−/− Gadd45a−/− mice was still comparable and much lower than WT and Gadd45a−/− mice, which indicated that deletion of Gadd45a has no impact on the cell intrinsic defects of immune system of ATM−/− mice (Fig. 1E and 1F).

Moreover, the expression level of PLP in the brain became comparable between 15 week-old WT and Olig1−/− mice, which indicated that the process of PLP expression to reach its optimal level might be delayed in the Olig−/− mice.

The expression of Ube3a was readily detectable and similar in liver tissues among m−/p+, m+/p−, and m+/p+ mice which indicated biallelic expression of Ube3a in non-CNS tissues (data not shown).