Sentence examples for mice which indicate from inspiring English sources

We have carried out a series of immunogenicity and protection studies following active immunization of mice, which indicate that a whole virus, nonadjuvanted vaccine is immunogenic at low doses and protects against live virus challenge.

Measurements of the auditory brainstem response (ABR) showed significantly elevated thresholds in homozygous mutant mice, which indicate severe hearing impairment.

In the treadmill experiment, the double-knockout mice exhibited longer shock times and more shocks compared with wild-type mice, which indicate locomotor disability.

We have included data from experiments using the orf73.stop mutant virus in both wild-type and mutant mice, which indicate that immune stimulation from the acute phase of infection is not responsible for the protection.

Down-regulation of XIAP expression in ovarian cancer cells results in apoptosis in vitro and prolonged survival of ovarian cancer-bearing mice, which indicate that XIAP may be a valuable therapeutic target in ovarian cancers [ 69].

Overexpression of PGC-1 α could significantly improve motor function and prolong the lifespan of ALS mice, which indicate that PGC-1 α may play a protective role in ALS [ 25].

Furthermore, we also observed an increased metastasis (one case of BM infiltration and one case of spleen infiltration) in ATM−/− Gadd45a−/− mice, which indicates that Gadd45a deletion increases the degree of malignancy of lymphoma in ATM−/− mice (Fig. 5D).

We have previously shown that GNPs are capable of inducing an antibody response in mice, which indicates that factors other than cytotoxicity may be involved and complicates in vivo application of GNPs [16].

Taken together, our results demonstrated the higher GCL and GPx activities in female mice, which indicated their crucial roles in regulating the resistance of liver injury induced by hepatotoxins in female.

Two and four months after transplantation, the percentage of donor-derived T-cells and B-cells in PB and BM of ATM−/− and ATM−/− Gadd45a−/− mice was still comparable and much lower than WT and Gadd45a−/− mice, which indicated that deletion of Gadd45a has no impact on the cell intrinsic defects of immune system of ATM−/− mice (Fig. 1E and 1F).

Moreover, the expression level of PLP in the brain became comparable between 15 week-old WT and Olig1−/− mice, which indicated that the process of PLP expression to reach its optimal level might be delayed in the Olig−/− mice.