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These findings correlate well with the previously described histopathological pattern in CNTF −/− mice which includes an increased OL apoptosis and also an enhanced axonal injury.
Interestingly, the lateral cortex of Psen cDKO mice, which includes visual and cingulate cortices, indeed shows the earliest and most striking neuronal death (Figure 4).
Gld mice have an abnormal phenotype similar to lpr mice, which includes lpr and autoimmune disease.
Lastly, a spontaneous tandem duplication within Fbn1 is responsible for the phenotype of tight skin (Tsk/+) mice, which includes myocardial, skeletal and pulmonary abnormalities of MFS and fibrotic features of SSS (see below) [ 43].
However, we have evidence that Sle2c2 also suppresses spontaneous autoimmune responses in two NZM2410-derived models [ 30, 31] and we have now shown that a low-dose treatment with G-CSF accelerates the spontaneous production of anti-dsDNA IgG in B6.TC mice, which includes Sle2c2 [ 19].
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Mice studied included four lines of wild-type mice which included: MF1, 129Sv, FvB and C57BL/6 (Harlan).
These results differed substantially from the ameliorating effects of CD treatment in NPC mice, which included a significant reduction of both cholesterol and GSL accumulation in treated Npc1−/− and Npc2−/− mice.
Several genes control resistance to Salmonella in mice, which include MHC (major histocompatibility complex) [ 25], SLC11A1 (Ity/Lsh/Bcg/N-ramp1), and toll-like receptor 4 (Tlr4) [ 26- 28].
A total of 479 mice, which included 425 RI strain, 25 LG/J, and 29 SM/J mice, were analyzed in this study (supporting information, Table S1 and Table S2).
For in vivo single unit extracellular recording, experimental groups consisted of 6 8 mice which included at least 3/4 male and 3/4 female subjects with more than one neuron recorded in each mouse.
In EphB3−/− mice, we observed significant functional improvement in hindlimb movement following SCI as compared with WT-injured mice, which included significantly higher levels of MBP in the cord.
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