Sentence examples for mice which however from inspiring English sources
While these skin abnormalities may be due to indirect effects, they suggest a role of PDX1 during skin development, which should be addressed in further studies, e.g. by analyzing keratinocyte-specific Pdx1 knockout mice, which however is beyond the scope of this report.
Lig4 homozygous mutations result in embryonic lethality in mice which however, can be rescued by Tp53 deficiency [31].
In line with this finding, our previous in vivo experiments showed that longer survival was associated with a significant reduction in ascites formation in IFN-α-treated mice, which, however, developed extracavitary masses 25.
Determination of Cnp mRNA expression in brains of young versus old mice revealed a remarkable decrease upon aging in Wt mice, which, however, still maintained levels above those in Cnp+/− mice (Fig 1K).
As αSD has never been detected in M83 mice younger than 4 6 months [ 4, 5, 10, 15, 17], this likely represents detection of normal human αS overexpressed in M83 mice, which however remains limited under these ELISA conditions.
We confirmed BAL findings with a histopathological evaluation of lungs in mice belonging in the same groups of mice, which, however, were not lavaged, so that histological evaluation would not be compromised.
Cholesterol accumulation also occurs secondarily to that of GM1 in these mice [30] which, however, do not accumulate significant amounts of GM2 and GM3.
However, other studies are contradictory and describe an accordance of blood urea nitrogen and creatinine levels with kidney damage in mice, which was, however, true only in pronounced radiation-induced kidney damage [35, 36].
Hyperkeratosis was also described in Keap1-deficient mice, which die, however, 3 weeks after birth from malnutrition due to hyperkeratosis in the esophagus (Wakabayashi et al, 2003).
In addition, when we took advantage of the endogenous IFN-γ and injected IDO1-knockdown B16 cells into wild-type mice, we found that IDO1 knockdown significantly suppressed B16 melanoma growth and prolonged the survival of mice (Fig. 8b), which however was effectively blunted by IFN-γ neutralizing antibody (Fig. 8c), further confirming that an IDO inhibitor requires the combination of IFN-γ IFN-γ
Recently we also reported the aortic protection from diabetes-induced damage with sulforaphane in a type diabetic mouse model, in which, however, we have used streptozotocin (STZ) to induce diabetic mouse model [ 44], as used most frequently by others [ 45- 48].
