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All of the infections occurred in rural areas where the deer mice, which harbor the virus, live.
These mice's guts were devoid of bacteria, unlike normal mice, which harbor hundreds of bacterial species in their bowels just as humans do.
Here we determined the effect of Ap4 deficiency on adenoma formation in the intestine of ApcMin mice, which harbor an inactivating mutation in one Apc allele.
We previously demonstrated that 3×Tg-AD mice, which harbor the human amyloid precursor protein Swedish mutant transgene, presenilin knock-in mutation, and tau P301L mutant transgene, exhibit significant alterations in overall myelination patterns and oligodendrocyte status at time points preceding the appearance of amyloid and tau pathology.
Furthermore, in DBA/2J mice overexpressing hTNNI3K, and in DBA.AKR.hrtfm2 congenic mice, which harbor the AKR/J "high-Tnni3k expression" haplotype in the DBA/2J genetic background, PR interval duration was prolonged as compared to DBA/2J wild-type mice ("low-Tnni3k expression" haplotype).
The autoimmune phenotype of IPEX patients is phenocopied in male scurfy (Foxp3sf) mice, which harbor a spontaneous mutation in the Foxp3 gene [16], [21], [22].
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To test the idea that SnCs might play a causative role in OA, we used the p16-3MR transgenic mouse, which harbors a p16INK4a (Cdkn2a) promoter driving the expression of a fusion protein containing synthetic Renilla luciferase and monomeric red fluorescent protein domains, as well as a truncated form of herpes simplex virus 1 thymidine kinase HSV-TK 15,16 HSV-TK 15,16
The Large myd mouse, which harbors a mutation in the glycosyltransferase gene Large and presents with aberrant glycosylation, faithfully models congenital muscular dystrophy type 1D.
The first mouse, which harbors a Cre- and Flp-dependent Mapt-doublestop-DTR (Maptds-DTR) knock-in allele, uses regulatory sequences in the Mapt/Tau gene to restrict diphtheria toxin receptor (DTR) expression to neurons.
7, 8 In genetic models utilizing the APCmin/+ mouse, which harbors a single allele mutation in apc, and therefore has intrinsically activated Wnt signaling, Schneider 9 demonstrated profound activity at dosages as low as 0.3 mg/mouse/day in reducing intestinal tumors.
In the eyes absent homolog 4 (Eya4−/−) mouse and the Tail-short (Ts) mouse (which harbors a deletion in the ribosomal-subunit gene Rpl38), craniofacial and Eustachian tube dysmorphologies result in abnormal clearance and/or drainage of the middle ear and Eustachian tube (Depreux et al., 2008; Noben-Trauth and Latoche, 2011).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com