Furthermore, mice which lack 5-HT2C receptors are reported to be hyperphagic (they develop obesity in later life) and hyperactive (Tecott et al., 1995), and to demonstrate less anxiety-like behaviour (Heisler et al., 2007b).
Furthermore, in mice, which only express CD1d molecules, iNKT cells were shown to be important for control of early infection [ 25- 27].
Furthermore, male mice, which are not prone to the metabolic disorder, had a reduced level of macroH2A1 incorporated into the Tbg promoter.
The HeLa cells of such tumours appeared to be unchanged in their ability to induce further tumours in ALS treated mice to which they were transferred and, furthermore, the mice which were carrying such tumours in the presence of immunological competence were able to reject additional injections of HeLa cells or other human tumour cells.
Furthermore, CD28-deficient mice, which are deficient for CD4+CD25+ T cells, are resistant to PGIA.
Furthermore, immunoproteasome deficient mice, which lack the LMP2, 7, and 10 catalytic subunits, show clear defects in presenting MHC class I epitopes, but no difference in the total levels of polyubiquitin conjugates measured by immunoblot (Kincaid et al., 2012).
Furthermore, it was demonstrated that Foxp3-deficient NOD mice, which are deficient in Treg cells, display an increased incidence and earlier onset of T1D compared with control NOD mice [44].
Furthermore, we isolated two monoclonal antibodies from sequentially immunized mice, which had potent broadly neutralizing activity against multiple influenza strains.
Furthermore, cytokeratin staining of tumors derived from M90TΔaroA-infected mice, which identifies pockets of 4T1 tumor cells showed reduced content of cytokeratin positive cells.
Furthermore, tyrosine phosphorylation of IRS2 is upregulated in these mice, which may impact upon long-term energy balance.
