Mice used were OT1 TCR transgenic mice, which express a TCR recognising the ovalbumin (OVA -derived peptide SIINFEKL, OVA -derivedransgenic mice, which expeptide TCR recogniSIINFEKL gp33-41 peptide or LCMV (KAVYNFATM).
The Ctgf Lo/Lo mice are similar in Ctgf expression level to the Ctgf heterozygous knockout (Ctgf KO/+) mice which express 50% of wild type Ctgf.
Mice carrying loxP flanked genes have for example been crossed with Cre-transgenic mice which express Cre in a cell-type-specific or inducible manner [ 11, 12].
We identified a novel HLA-DR4-restricted CD4+ T-cell epitope on a secreted antigen of Mycobacterium tuberculosis, MPT51, in 004149-MM HLA-DR4-transgenic mice which express HLA-DRB1*0401, but not murine MHC class II molecules.
HHD mice which express human HLA-A2 but no mouse class I, have been shown to have improved cytotoxic lymphocyte (CTL) responses to foreign antigens compared to HLA*A201/Kb transgenic mice.
KrasG12D/+ Trp53R172H/+ Pdx-1-Cre (KrasG12D/+ Trp53R172H/+ Pdx-1-Created form of KPCs in pancreatic tissues, develop pancreatic intraepithelial neoplasmicePanIN) that progress to pancreatic ductal adenocarcinoma (PDA).
BC extraction of brain tissue from C100 transgenic mice (which express human Aβ but do not develop amyloid) revealed SDS-resistant dimers as Aβ was mobilized from the sedimentable to the soluble fraction.
Nevertheless, transgenic mice which express the whole HCV polyprotein (HCV-Tg) do not develop HCC.
Similar results have been seen in transgenic mice which express hVEGF-A165 in the liver [18], [29] [30].
Other clones were derived from the Thy1-YFP 2.2 mice, which express YFP under a neuronal specific promoter [18].
These animals were crossed with Amh-Cre mice, which express Cre recombinase specifically in Sertoli cells from E15 onwards [20].
