In this work, we studied the after hours (Afh) mutant mice, which exhibit a lengthening of the circadian period.
When neonatal humanized UGT1 (hUGT1) mice, which exhibit severe levels of total serum bilirubin (TSB) because of a developmental delay in expression of the UGT1A1 gene, were treated with PEITC, TSB levels were reduced.
Using gene microarrays, we compared gene expression patterns in the somatosensory cortex of wild type and ephrinA5 deficient mice, which exhibit subtle, but highly reproducible alterations of thalamocortical projections and intrinsic cortical circuits.
To investigate this, opiate-induced brain metabolomic responses were profiled using a semi-targeted method in C57BL/6 and 129Sv1 mice, which exhibit extreme differences in their tendency to become opiate dependent.
Here, we examined the effects of early life maternal separation (MS) stress on anxiety-like behaviour and behavioural disinhibition, a type of impulsivity-like behaviour, in wild-type (WT) and tryptophan hydroxylase 2 (Tph2) knock-in (Tph2KI) mice, which exhibit ~60-80 ~60-80tions in the levels of brain 5-HT due to a R439H mutation in Tph2.
BDNF overexpressing mice, which exhibit a precocious development of intracortical inhibition, also show an accelerated development of visual acuity [29].
Further evidence for this hypothesis was recently demonstrated in AKAP12 knockout mice, which exhibit prostatic hyperplasia and focal dysplasia [26].
The biological action of myostatin is well described in myostatin-deficient mice, which exhibit muscular hyperplasia and hypertrophy [21], [67].
Indeed, this is exactly what is observed in JNK1-/ mice which exhibit pre-disposition to intestinal tumour formation [20].
Additional major support for the importance of Y2 receptors in the regulation of energy homeostasis comes from germline Y2 receptor knockout mice, which exhibit reduced adiposity [26].
These mice, which exhibit intolerance to their intestinal microbiota develop spontaneous colitis as the result of microbial-induced activation of effector T cells [17] [19].
