Expression of a constitutively active Ha-ras in transgenic mouse urothelium elicited early-onset hyperplasia in all the mice, sixty percent of which eventually evolved, in mice older 10 months of age, to low-grade, non-invasive carcinomas that strongly resembled the human counterparts [ 50].
Specifically, we show that Vav2/Vav3-deficient mice have elevated IOP, which eventually manifests as buphthalmos.
The brachiocephalic artery of fat-fed ApoE deficient mice develops complex plaques, which eventually spontaneously rupture [12].
We infected the mice with P. multocida, which eventually led to the development of septicemia, This murine lung infection model was also used to elucidate the magnitude of the fAUC0-24h/MIC index required for various effects.
After 28 days, treatment was stopped and mice were again followed for tumor recurrence, which eventually developed in about half of the mice.
These images would illustrate the story that the author Laura Numeroff had written for a children's book, "If You Give A Mouse a Cookie" (Harper Collins, 1985), which eventually sold 11 million copies and inspired a beloved series.
In mouse mammary epithelium, it stimulates proliferation, which eventually culminates in glandular development.
The intensity of the fluorescence signal in the tumors increased rapidly in mice injected with both types of probes, which eventually peaked between 4 and 6 h.
By characterizing mice that have the Traf3 gene specifically deleted in B lymphocytes (B-TRAF3-/ mice), we found that TRAF3 deletion causes vastly prolonged survival of mature B cells independent of BAFF, which eventually leads to B lymphoma development in mice [ 4, 14].
Like mdx mice, hypertrophic MSV ski transgenic mouse muscles have muscle degeneration that is initially efficiently repaired, but which eventually shows defective regeneration and frank muscle defects.
