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These results are consistent with the hypothesis that CB1R activation suppresses recurrent excitatory activity in epileptic mice, which does not occur in the granule cell layer of control mice.
A brain homogenate from Tg WT) mice expressing 3F4-tagged mouse PrPC [16] was seeded with PrPSc immunopurified from RML-infected C57BL/6 mice (which does not contain the 3F4 epitope), and the mixture was subjected to 90 cycles of sonication and incubation at 37°C.
However, these two studies came from experiments conducted on small numbers of knockout mice, which does not provide sufficient basis for a conclusion.
Cell autonomy is also supported by a similar phenotype in combination with the Plp-CreERT2 transgene and tamoxifen treatment of adult mice, which does not lead to recombination in (embryonic) neuron glia progenitors.
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One theory is that Babesia may be carried primarily in mice, which don't tend to travel far afield.
Type I collagen had an initial degraded pattern in the skin of CyC-AP-null mice, which did not occur in wild-type mice.
The immunocompromised mice, which don't have T cells, get significantly lower scores on the same cognitive tests given to the healthy mice.
Analysis revealed development of OA-related gait asymmetry in vehicle-treated STR/Ort mice, which did not emerge in SFX-01®-treated mice.
Even in those mice which did not develop overt DM, there was a significant delay in onset of hypoglycemia (ie: median 129 d; P = 0.0008).
Prototypes of CSS may be tested for safety and efficacy by grafting to athymic mice which do not reject human tissues.
At night, the camera relied upon infrared light (infrared light is invisible to mice), which did not interfere with motion detection.
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