Another issue is that many studies injected GBM in the dorsal flanks of mice, which do not recapitulate GBM in human.
Prototypes of CSS may be tested for safety and efficacy by grafting to athymic mice which do not reject human tissues.
Escalating morphine doses (10 40 mg/kg) administered over a 4-day period selectively induced a twofold decrease (p < 0.00005) in adenosine abundance in the brainstem of C57BL/6 mice, which exhibited symptoms of narcotic drug dependence; but did not decrease adenosine abundance in 129Sv1 mice, which do not exhibit symptoms of dependence.
A group of Leicester, England-based researchers simulated the process of hibernation in mice, which do not do so naturally, and identified a process for preventing the loss of brain cells and the connections between them.
We compared the methylation density in this element with other IAPs in Avy mice, which do not appear to show epigenetic variation.
To assess the possible involvement of host IL-2 in the HSV-IL-2-induced demyelination, we used BALB/c-STAT4−/− mice, which do not mount a TH1 response, and BALB/c-STAT6−/− mice, which do not mount a TH2 response.
To generate viable Relb-deficient mice, these were bred with Tcra-deficient mice, which do not express the αβ T-cell receptor (TCR) and therefore lack mature T cells.
BACE1 knockout (KO) mice that generate low levels of Aβ and BACE1- and BACE2-deficient double KO mice, which do not express Aβ, have mortality rates of 40 and 60 percent, respectively.
Most importantly however, we observed that 24 weeks old Krm2-deficient mice, which do not display a phenotype at younger age [38], are characterized by a marked increase in bone formation.
A study [26] has noted differences in estrogen receptors levels between BALB/c mice, which do not get autoimmune disease and two strains that do (MRL/MP-lpr/lpr and NZB/W mice).
In contrast, activation of a subset of Notch target genes occurs in pre-malignant thymocytes of Hes1 transgenic mice, which do not carry mutations in the PEST domain (data not shown).
