Something in the blood of young mice has the ability to restore mental capabilities in old mice, which could spell a new paradigm for recharging aging brains.
Serum measurements confirmed decreased 1,25(OH)2D levels in CKD mice, which could be successfully corrected by Vit D injections.
Geneticist Mark Kay uses a gene-therapy technique known as RNA inihibition to switch off genes in mice, which could point toward development treatments for cancer, hepatitis C and AIDS.
A possible explanation for this phenomenon could be due to a 'minimal' or 'low' level of anxiety response induced in the TTC9A−/− female mice which could possibly result in no significant changes in the open-field center zone duration.
They looked at defective mice which could not produce these fat cells.
In consideration of elevated NK cells in the lung, researchers eliminated NK cells in these mice, which could not restore the pulmonary metastasis yet.
This does not exclude the hypothesis of an epigenetic and silencing defect of the paternal X chromosome in those mice, which could explain the sex-ratio distortion observed.
To circumvent these problems, we generated NFAT5Flox/Flox mice which could be used to inactivate NFAT5 in a tissue-specific manner.
Consistently, neo-intima formation after femoral cuff placement was increased in Cav-1 null mice, which could be reversed by addition of a MMP-inhibitor.
The over-expression of this DNA methyltransferase could decrease SAM level and the SAM/SAH ratio in liver of Ts65Dn mice, which could influence the methylation index and then the gene expression.
In contrast to our findings, Hansotia et al. recently reported increased energy expenditure in single and double incretin receptor knockout mice, which could partly be attributed to increased locomotor activity in the dark phase [32].
