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The diffuse deposits in bitransgenic mice, which contain primarily wild-type Aβ42, accumulate in regions both with and without transgene expression.
(A) TEM micrograph of sinusoid in normal mice, which contain numerous sieve plates with open fenestrae.
Several clones were obtained from ROSA26 mice, which contain a transgene encoding a ubiquitously expressed bacterial β-galactosidase [17].
We also isolated DNA from skeletal muscle (and liver) of R26 mice, which contain the LacZ transgene in all the nuclei (and from whom the R26 ESCs were derived), as well as DNA from skeletal muscle (and liver) of WT and of mdx mice, which contain no LacZ transgene.
Interestingly, in GAD67-GFP knock-in mice, which contain all endogenous regulatory sequences, there is no GFP expression in newborn dentate granule cells [54, S. Zhao and G. Feng, unpublished observation].
CFSE-labeled CD4 T-cells from wt or CD28 knockout mice (which contain about 10 and 2% Treg cells, respectively) were transferred to CD28 wild type mice, which were then challenged with the CD28SA and analyzed for proliferation 3 days later.
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It is present at a low level in the testes of 6 days old mice which contained only primitive type A spermatogonia.
Dazl1 and Dazap1 transcripts were also present in the testes of Wv/Wv mutant mice which contained diminished number of germ cells [ 18].
The domain of Ngn3 deletion was confirmed by crossing Nkx2.1iCre/+ mice with R26R homozygous mice, which contained floxed lacZ alleles in the Rosa26 locus (Soriano, 1999) in order to trace the location of iCre recombinase activity.
(E ) In mechanically dissociated bone marrow from Angpt1 GFP mice (which contains hematopoietic but not stromal cells) 85% of GFP+ cells were c-kit+ and 76% of c-kit+ cells were GFP+ (n = 4 mice from 4 independent experiments).
There are around 80 genes in the triplicated segment common to Ts65Dn and Ts1Cje mice, which contains the DS critical region (DSCR) of chromosome 21 (Delabar et al., 1993, Toyoda et al., 2002).
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