Sentence examples for mice where we from inspiring English sources

We validate our method on both in-silico generated data using Monte Carlo simulations and an in-vivo test-retest study of two C57Bl6 wild-type mice, where we found good reproducibility of estimated qτ-index values and trends.

This approach is based on studies in mice where we could recently demonstrate increased brain tissue concentrations of insulin and increased insulin signaling in the hypothalamus and cerebral cortex following peripheral injection of insulin detemir.

This is in contradistinction to the state of this circuitry in serotonin transporter KO mice where we observed more robust connectivity in more posterior brain regions using methods identical to those employed here.

The same phenotype was observed in male transgenic mice, where we also found a more than 4-fold reduction of the trabecular bone volume compared to wildtype littermates at 24 weeks of age (data not shown).

Our study with RU486 did not reproduce completely the same bone phenotype as the PRKO mice, where we observed RU486 treatment induced less bone gain compared to the RPKO, suggesting the possible involvement of progesterone extra-nuclear signaling in the regulation of bone cell activities.

This is supported by our recent observations in mice, where we found that exendin-4 neutralizing antibodies were detected in mice exposed to Ex-4 but not to Ex4-IgG-Fc (Liang YM et al unpublished data), consistent with the tolerance effect of IgG carrier proteins [35]; [35].

Interestingly, they even found 5' bias in human and mouse, where we did not observe it.

Contrary to mouse, where we found expression level differences of over 10-fold between TSSs, in human samples, the difference in expression between the three TSSs was less than 2-fold.

In our previous study we compared the bone of male mice deficient for α7-nAChR (α7KO) compared to their corresponding wild-type mice (α7WT) where we did not find significant differences [ 10].

To confirm our in vitro observation of doxorubicin downregulation of B7-H1 in an in vivo system, we used a mouse model where we xenotransplanted MDA-MB-231 in nude mice in the mammary fat pad to closely mimic human breast cancer.

These results illustrate our ability to generate a mouse model where we can ablate Tcf7l2 overexpression specifically in beta cells of adult mice, while preserving overexpression in peripheral tissues.