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Results of pathogenicity experiments indicated that death can occur from the i.c. and i.m. routes of injection, although gt2 viruses showed lower lethality to mice when injected i.m.
Although neither immune serum nor T cells or B cells (from arthritic animals) appear to be capable of transferring PGIA to SCID mice when injected alone [ 12, 13], mild and transient synovitis is observed after co-injection of immune serum and T cells (but not B cells), and this mild inflammation can even be extended by repeated administration of immune serum ([ 27] and our unpublished data).
Even better, the researchers say, the immune system cells from these mice, when injected into nonresistant mice, will cure their cancers.
Viral vectors based on adeno-associated virus 8 or canine adenovirus that have been described as enabling fast (48 h–6 days) expression in vitro29,30 led to insufficient, if any, expression of channelrhodopsins (ChRs) in the PL of the PFC from P5 10 mice when injected in vivo 1 2 days after birth.
Last year, a team led by James Paulson, a chemist at the Scripps Research Institute in San Diego, California, who leads the lab where Rillahan did his work on P-3Fax-Neu5Ac, found that the drug caused fatal kidney damage in mice when injected into the bloodstream.
Nude mice, when injected with SkBr3/HOXB7 cells, developed tumors [ 21].
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Of these, three could also pull off the trick of making a mouse when injected into a tetraploid blastocyst.
In one surprising result, researchers showed that brain cells from adult mice can, when injected into early mouse embryos, become cells in the heart, stomach, liver, and other organs of a developing fetus.
These cells grow robustly in vitro and express many prostate and epithelial markers, yet they grow poorly in mice even when injected into the mouse prostate gland.
Nevertheless, both T-oligos demonstrated anti-tumor effects as determined by mice survival when injected intravenously into SCID mice previously injected with MCF-7 cells.
The major finding of our study is that RGE had a novel therapeutic effect against even the most aggressive models of malignancy in mice only when injected.
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