Sentence examples for mice when crossed from inspiring English sources
Autoimmunity and fatal SLE nephritis develop in NZB mice when crossed with TNFα-deficient mice [ 34].
Alb-Cre mice, when crossed to Ppp2cαloxp/loxp mice, provide a tool to generate mice with liver specific deletion.
Heterozygous male mice were identified as phenotypically normal mice that produced litters comprising phenotypically normal mice and Gdf5bp mice when crossed with Gdf5bp females.
This might in turn explain how a genetic reduction of Tau could lead to a reduction of seizure susceptibility in hAPP mouse models when crossed with TKO mice [ 52] and even in non-AD related epilepsy models [ 53, 54].
In order to link expression of the PyV mT oncogene with that of Cre recombinase in an inducible manner, we generated a TetO-PyV mT-IRES-Cre recombinase (MIC) transgenic mouse that, when crossed to the MMTV-rtTA strain and treated with doxycycline, expresses both PyV mT and Cre recombinase from the same bi-cistronic transcript in the mammary epithelium.
The SIRT1 knockout mice undergo embryonic lethality, nevertheless the SIRT1 mouse develops tumors when crossed with the p53 −/+ mouse.
His laboratory has successfully developed a tissue-restricted MMTV-driven reverse tetracycline-controlled transactivator (rtTA) transgenic mouse line that, when crossed with a TetO-c- myc mouse line, was able to generate mammary tumors when activated with doxycycline.
The HPA axis defect associated with 11β-HSD1KO micancan be rescued when crossed with liver-specific HSD1-overexpressing mice (24), thus it seems that hepatic GC output can modulate HPA axis sensitivity.
Muc1 knockout mice (Muc1-/; MUC1 is human; Muc1 is mouse) show a reduction in tumorigenic phenotype when crossed onto mice overexpressing the Wnt-1 [ 7] or polyomavirus middle T antigen [ 8] oncogenes in the mammary gland.
IL-1 receptor antagonist-deficient (IL-1Ra−/−) mice develop spontaneous arthritis, but when crossed with TLR4−/− mice, disease severity is reduced [ 19].
As they generated more oncomice and knockout mice, the mouse models with individual gene target provided even more information when crossed with mice with various genetic backgrounds.
