Our model using an outbred strain may recapitulate the variability described by Nonogaki and coworkers and suggests that at the "population" level, male mice are vulnerable to obesity only when faced with HFD.
Behavioral analyses revealed no differences from wild types, but mutant mice were more vulnerable to kainate-induced seizures.
For example, Abdul et al [11] reported that cortical neurons cultured from APP/PS1 transgenic mice were more vulnerable to oxidative stress, mitochondrial dysfunction and apoptosis.
Data also proved that Ind mice were remarkably vulnerable to HFD-induced obesity and that exposure to hypercaloric and highly palatable diet was able to reverse the effects observed under standard diet, i.e. lower food intake and weight loss.
In addition, the livers and kidneys of ARD1 transgenic mice were more vulnerable to oxygen toxicity.
In addition, cultured RGCs prepared from EAAC1 KO mice were more vulnerable to oxidative stress.
Hippocampal neurons in αCaMKII promoter-driven dominant negative ActRIB transgenic mice were more vulnerable to kainate injection [ 105].
26 PGC-1α KO fibroblasts exhibit a decrease in SOD2, catalase, and GPx1 mRNA content relative to WT fibroblasts and PGC-1α KO mice were more vulnerable to oxidative stress.
And Liu et al. (2011) demonstrated that cortical neurons isolated from OGG1-deficient mice were more vulnerable to oxidative stress than that of normal OGG1 mice, and OGG1-deficient mice developed cortical infarcts and behavior deficits after cerebral artery occlusion [ 33].
The research, conducted at Washington University School of Medicine in St . Louisand published in the Journal of Clinical Investigation, found higher levels of a blood vessel receptor protein called S1PR2 in both female mice and women who were vulnerable to MS. What's more, S1PR2 was even higher in the parts of the brains of the women and mice that MS usually affects.
