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Lesion-infiltrated MØ of young ApoE KO mice were virtually all Arg I+ suggesting that they were of the M2 phenotype.
Interestingly however, the serum insulin levels of Nscl-2 mutant mice were virtually normal while ob/ob mice, which are a model of Type II diabetes [25], showed a massive increase in serum insulin concentrations (Fig. 8A).
Swimming speeds of S14G-HN treated and control mice were virtually the same in probe test (data not shown), indicating that locomotion activity was not affected by S14G-HN.
Not surprisingly, the DRG and roots of symptomatic mice were virtually flooded with both macrophages and CD8+ T cells, where DRG sensory neurons were barely observable.
Interestingly, breathing differences between UBB+1 tg and control mice were virtually absent when the hypercapnic challenge of 3%% CO2 was added to the hypoxic challenge.
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Apart from abnormal movements such as clasping, and mild impairments in gait, these mice are virtually indistinguishable from wild-type mice.
Our initial time course studies are in line with these findings and show that the microgliosis and dopaminergic neurodegeneration in B10.BR mice are virtually resolved respectively by days 4 and 7 post-MPTP injection (Figure 6, right and middle panels, respectively).
We found that hepatic glycogen in WT mice was virtually absent after 24 hours of fasting whereas RasGrf1 −/− mice maintained significant glycogen levels.
The BM cells of mice are virtually exposed to DZNep intermittently, because its concentration in mice plasma is lowered to less than 10% within 30 minutes after administration.
The phenotype of the TGF-β1 and TβRII knockout mice is virtually indistinguishable and is characterized by defective endothelial differentiation resulting in abnormal capillary tube formation [ 61, 62].
As the tidal volume up to about 4 ppm FA in mice is virtually constant, the respiratory ventilation is halved at the RD50, resulting in decreased oxygen supply in mice and presumably hypoxia-induced stress reactions.
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