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As controls, mice were untreated or insufflated with oxygen only.
Thereafter, the mice were untreated for two days and the saccharin intake was measured these days as well.
The last day, when the mice were untreated, we found an overall main effect of previous treatment on saccharin consumption (g/kg) [F 2,12) = 15.092, p = 0.0005] as well as on saccharin preference [F 2,12) = 34.92, p<0.001].
After treatment the mice were untreated for two days and there was no difference in saccharin intake between mice subjected to different treatments (vehicle 0.05±0.005 g/kg/3 hrs; JMV2959 0.05±0.003 g/kg/3 hrs) [F 1,23) = 0.533, p = 0.473].
Control mice were untreated, but received doxycycline in the drinking water.
When blood samples were analyzed, they were predominantly negative, even when the mice were untreated (Fig. 3C).
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The fourth group (10 mice) was untreated and used as a normal control group.
However, the diabetes in these mice was untreated and it is unclear if the results can be compared with this human population where both diabetes and sepsis were treated aggressively.
Controls were untreated naive mice.
Control groups included J8-DT immunized mice, which were untreated or treated with normal rat IgG (nRIg), and PBS immunized mice which were treated with anti-CD4/anti-CD8 mAb or nRIg.
Control samples were from the mice that were untreated (day 0).
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