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To manipulate estradiol, adult gonadectomized mice were treated with chronic implants containing estradiol or no hormone.
To evaluate early morphologic responses to MPA or progesterone on the mammary gland, C57BL/6 and BALB/c mice were treated with MPA or progesterone, or implanted with blank silastic pellets for 4 or 8 weeks, after which the animals were killed and the mammary glands excised and processed for whole mount or hematoxylin and eosin studies.
Subsequently, groups of tumor implanted nude mice were treated with [Cu]CuCl2 to simulate single- and multiple-dose therapy protocols, and results were analyzed to estimate therapeutic efficacy.
MDA-MB-435S cells were implanted into the mammary fat pad, and starting two days post-implantation, the mice were treated with control, Src+STAT3, or Src+STAT3+Myc siRNA.
PC-3 cells (5 × 10) were implanted in the prostates of nude mice and the mice were treated with alendronate (0.5 mg/kg/day in PBS, s.c).
In 44 cases, mice were treated with the drug or drugs most likely to be used in the patients and the effects on the implants were assessed histologically.
Five mice were treated with HDM.
Twenty four hours later, these mice were treated with IFN-γ.
These diabetic mice were treated with PM1 (100 mg/kg, i.p).
As a control, mice were treated with saline.
Control mice received 200 μL of saline, while blank mice were treated with unloaded ANPs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com