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The researchers found that, at death, the only surviving motor neuron cells in the mice were those that had been "infected" with the virus and contained Cas9 protein, said Thomas Gaj, a postdoctoral fellow who led the study, now at the University of Illinois at Urbana-Champaign.
One group of proteins significantly altered in null mutant mice were those involved in oxidative stress and cellular redox homeostasis (p<0.0001).
Multiple regression analysis (F[3,89] = 4.111, p<.001) revealed that the odorants investigated longest by mice were those rated most pleasant by humans (t 89) = 2.232, p<.003) (Fig. 1A).
Bio-functions and pathways up-regulated in Tg mice were those associated with oxidative stress, cell injury, inflammation, nervous system development, neuronal growth, and synaptic transmission.
Supersusceptible and resistant classes were fundamentally based on survival, whereas susceptible mice were those that survived to day 35 without external evidence of morbidity but had lost weight upon retrospective analysis.
The main functional categories and molecular pathways of the genes that were over-expressed in the Glud1 mice were those of cell responses to oxidative stress, cell injury, and inflammation, as well as those of nervous system development, neurite growth, and synaptic transmission.
Similar(54)
The β2KO mice are those produced by targeted gene disruption (Chruscinski et al., 1999).
No such decrease is detectable in Mcl-1f/fLckCreBax−/−, indicating that most of the cells in these mice are those that have escaped deletion.
The sequences of the 7 genes in the CASP mice were the same as those in the C57BL/6J mice.
The expression values of the cerebral cortex of RF-exposed mice were normalized to those of the sham-exposed mice.
The behavioral outcomes shown in A30 mice were different from those of S30 mice, despite equivalent sweetness of the aspartame solution to that of the sucrose solution.
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