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The expanded place fields in hippocampal neurons of DNRAb + mice were sustained up to 9 weeks (Fig. 4E).
Fasting TG levels in MTMR14 KO mice were sustained higher than age-matched WT controls after 30 weeks of feeding a normal chow diet (Table 1).
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Whereas thymic output in mice is sustained on to high age, thymic involution drastically reduces T cell replenishment in adult humans (den Braber et al., 2012).
It is postulated that, had the high levels of LTβR-Ig observed in 12-week-old mice been sustained throughout the experiment, the protective/reversal effects of LTβR-Ig would have been more pronounced.
The higher burden of Δ isp2/3 parasites in mice was sustained until day 3 after infection (Fig. 7B), but became approximately equivalent to that of WT by day 5 (Fig. 7C).
However, the drop in gene expression observed with the HDV was primarily due to the adaptive immune response, since both β-galactosidase expression and vector genome were sustained in immunodeficient mice treated with HDV.
In contrast, the TRACP5b levels were sustained in 100 mg/kg ZSTK474-treated mice.
Interestingly, the differences were sustained in vitro in cells explanted from young and old mice.
These regressions were sustained for the designated experimental period (100 days) in two out of five mice.
Miraculously, the improvements were sustained.
Consonant with diminished urinary creatinine excretion, and presumably a decline in the glomerular filtration rate, urine volume declined in γ3 +/+ and +/- mice, but was sustained at relatively normal values in γ3 -/- mice over the period of timed sacrifice (data not shown).
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