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Biochemical markers showed that livers, hearts, and kidneys of treated mice were substantially unaffected by the administration of 3, despite the presence of the potentially toxic nitro group.
The brain levels of Abeta42 in PDAPP/TRE4 mice were substantially elevated even at this very early time point.
On the other hand, PrPSc deposition profiles in Tga20 mice were substantially different between the strains 22L, ME7 and RML and did not correlate with the level of PrPC overexpression in these mice (Tables 1, 5 and Fig. 5).
The levels of IFN-γ, IL-17, IL-6, IP-10, KC, MCP-1 and TNF-α in the lungs of all mice were substantially higher at 4 days post-challenge, as compared to at 1 day (Fig. 6).
Likewise, virus titers in other organs and serum of the rZH501-M847-G-infected mice were substantially lower than those of the corresponding organs of rZH501-M847-A-infected mice.
We showed that baseline urine Hep-2 levels of DBA/2 mice were substantially higher than that of the other mouse strains and that i.v. iron administration significantly increased urine Hep-2 levels in C57Bl/6 mice, which is in agreement with previous reports on mouse liver hepcidin-2 expression [7], [14].
Similar(39)
Expression of osteoclasts in osteopetrotic (op/op) mice is substantially reduced by the absence of functional macrophage colony-stimulating factor (M-CSF).
High cholesterol levels found in APOE knockout mice are substantially corrected in the APOE transgenic lines.
The enhancement of the survival rate in CSQ/betaARKct mice was substantially potentiated by chronic treatment with the betaAR antagonist metoprolol (CSQ/betaARKct nontreated vs. CSQ/betaARKct metoprolol treated, 15 +/- 1 weeks vs. 25 +/- 2 weeks, P < 0.0001).
Induced levels of cAMP in platelets and in brains of fmr1 knockout mice are substantially reduced.
In addition, the viral burden in the CD62L+ CD8 T cell transferred mice was substantially lower compared to CD62L− CD8 T cell transferred mice (Fig. 4c).
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