Cardiomyocytes from adbn−/− mice were smaller and responded less to adrenergic receptor induced hypertrophy.
Similarly, tamoxifen-treated WT mice were smaller than their untreated counterparts, partly due to smaller muscles (Supplementary Tables 2, 3), and presumably also because of reduced amount of white adipose tissue, which was evident upon dissection and similar to our observation in dystrophic mice reported earlier36.
On arrival, all of the apoE−/−mice had similar weights, but by the time of study, the diabetic mice were smaller than the non-diabetic mice with average weights of 23.1 ± 1.2 and 30.7 ± 1.1 g (P = 0.0001).
These mice were smaller, possessed smaller and paler kidneys, were proteinuric and died between 3 24 weeks of age.
However, we observed that DLC2-deficient mice were smaller and had less adipose tissue than the wild type mice.
Size of bbee mice were smaller than wild-type (BBEE) mice; and their hair was rough (Figure 1A).
Although DLC2 deficiency did not lead to embryonic lethality, DLC2-deficient mice were smaller and had less adipose tissue.
Because the Hdac3 CKO mice were smaller than wildtype and heterozyogous littermates, we also examined growth plates in skeletally immature mice.
The smDicer mutant mice were smaller and weighed 73% of its WT or heterozygote siblings measured at 20 21 days (n = 5).
Unexpectedly, nNOSμ-deficient muscles from male mice were smaller in mass and generated significantly lower maximum isometric force compared with littermate controls.
Macroscopically, lymphoid follicles in wild-type mice were smaller and markedly irregular in shape compared to MyD88-deficient mice after infection.
