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Of note, the absolute numbers of CARcs in femurs of aged mice were slightly increased compared to young mice, likely due to the augmented volume of femoral cavities as a consequence of the gradual loss of trabecular and cortical bone density associated to ageing (Fig. 7d f).
No significant difference in body weight was observed between the mice treated with 10% ribitol from the embryonic stage, those treated with 5% ribitol from 7 weeks of age, or the age-matched untreated P448L mice at all time points, although treated female mice were slightly heavier than the controls (Supplementary Figure 9b).
(Female mice were slightly more sensitive to the effect).
DDT-exposed female mice were slightly heavier and carried a bit more fat as young adults - two to five months after birth.
Previous study had suggested that mutant mice were slightly smaller at weaning than WT and heterozygote littermates [12].
The lungs harvested from CC-3052 treated mice were slightly enlarged compared to those from IgG1 control mice (Figure 6C).
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The T cell priming capacity of anti-CCR2 treated mice was slightly higher than IgG isotype control-treated mice.
However, the percentage of CD44+CD62L− T cells from lymph nodes of Rag2 KI mice was slightly increased (Fig. 3B,C).
As compared with control mice, while the mRNA expression of pro-inflammatory mediators (IL-1β, TNFα and iNOS) and pro-fibrotic cytokine (TGF-β1) was significantly elevated in the lungs of BLM-injected WT mice, the expression of these mediators in the lungs of Ninj1 KO mice was slightly induced but significantly less than WT mice (Fig. 4A).
The median survival age of male uko/3cv mice was slightly longer than that of female.
Moreover, Als2-null mice are slightly vulnerable to oxidative stress [28].
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