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The Pank1−/− mice were severely compromised in the pyruvate challenge.
Macrophages from cIAP-1 KO mice were severely affected in bactericidal innate immune signaling pathways.
By 4 weeks of age and older, Lmna-/ mice were severely runted compared to Lmna+/+ mice (Figure 1A).
Interestingly, αB-crystallin/HspB2 deficient transgenic mice were severely impaired in locomotion compared to each genetic model separately.
Comparing individual high activity behaviors for leptin KO mice versus WT controls before scheduled feeding demonstrates that leptin KO mice were severely hypoactive, consistent with other studies [34].
The walking movements of the mice were severely altered after treatment with the BK channel blocker; mice frequently slipped on both fore- and hind-limbs, resulting in loss of balance on the bar.
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Nesting behavior in young Ts65Dn mice was severely impaired when the animals were placed in a novel environment.
The hair cell population in the cochleae of the Gjb2-CKO mice was severely depleted but in the vestibular organs it was intact, despite absence of Cx26 expression.
Acute virus replication in murine (M) CMV infected C57BL/6 (Cmice) mise iseverelylimitedted by Ly49H+ NK cells, but not in MCMV infected BALB/c or BXD8 (Cmice) mice that lack Ly49H+ NK cells.
Eye phenotypes in mice are severely influenced by genetic background.
Dental enamel in K14-Cre p120-cKO mice was severely malformed.
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