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Thymi and spleens of 4-week-old p53−/−Mysm1−/− DKO mice were roughly of normal size.
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However, one disadvantage of using NOD-scid mice is that due to the rate of spontaneous fatal thymoma formation the average lifespan of NOD-scid mice is roughly 8.5 months (34 weeks) limiting the length of studies that can be performed [59], [60].
The magnitude of airway eosinophilia in Rag1−/− mice was roughly comparable to that in the wild type BALB/c mice for up to 5 days; airway eosinophilia further increased at a later time point in the wild type but not in Rag1−/− mice.
With regards to intestinal morphology and enzyme production, small intestines from postnatal day (P 14-P16 P 14-P16e) mimmatureroughly equivalent to that of a humicefetus, are24 weeks of gestation, that is proughlysequivalentlop NEC (Henning, 1985; Montoomery ethat., 1999; Sandersof and Walker, 1999; McElroy and Weitkamp, 2011).
Most CR studies in animals employ a reduction in calories by 30%% or greater, and as discussed previously, such a restriction in mice is roughly comparable to a 1 week water-only fast in humans [ 23], both options that may not be reasonable for the cancer patient.
Along these lines, fasting for 1 day in the mouse is roughly comparable to a 1-week water-only fast in a human [ 23].
There were no significant differences in the fraction of each cell type produced indicating that cultures from both mouse strains were roughly equivalent in their native differentiation profiles (Fig. S7).
While these features were present in both transgenic lines, brains from symptomatic mice from both lines were roughly twofold smaller than age-matched non-transgenic (NT) mice (Fig. 2e, f).
p53−/−Mysm1−/− DKO mice were born roughly at Mendelian ratios, but with clear preference for male offspring.
The virus titers in the liver of rZH501-M847-G-infected mice at 2 days p.i. were roughly ten times lower than those in the liver of rZH501-M847-A-infected mice (Fig. 4).
For stimulated secretion, a static assay of intracellular mucin content (image analysis in Figure 3B) shows impaired release in SNAP23 Het mice that is roughly commensurate with the level of SNAP23 protein.
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