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All rIL-25-treated mice were refractory to infection.
By contrast, C/EBPβ-Ala217 mice were refractory to the induction of HSC activation and proliferation by CCl4 treatment (Figure 4A and B).
The quantitative analysis of liver collagen, the major extracellular matrix protein in liver fibrosis [4], with the Sirius red collagen-binding assay [19] (Figure 1C), demonstrated that C/EBPβ-Ala217 mice were refractory to the development of liver fibrosis after chronic exposure to the hepatotoxin.
WT CLP mice were refractory to β-stimulation, while eNOS-/ CLP mice responded comparably with sham-operated WT mice.
As expected, Klb deficient DIO mice were refractory to bFKB1 as measured by energy expenditure (Fig. 8B) and glucose tolerance (Fig. 8C).
As chronic increases in hepatic gluconeogenesis and disrupted lipid metabolism contribute to the development of T2D, we examined whether LMKO mice were refractory to T2D development.
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We demonstrate that CD47 mice are refractory to experimental autoimmune encephalomyelitis (EAE), primarily as the result of failure of immune cell activation after immunization with myelin antigen.
Using the CR model, we then attempted to verify the published result that orexin deletion diminishes food anticipatory activity (FAA) but observed little to no diminution in the response to CR and, surprisingly, that orexin KO mice are refractory to body weight loss on a CR diet.
Moreover, TLR9 knockout mice are refractory to lethal shock from synthetic oligonucleotides bearing unmethylated CpG motifs that rapidly induce refractory hypotension and lethality in wild-type mice.
Our data suggest that an area colonized by mice is refractory to further introgression, possibly due to fast adaptations of the resident mice to local conditions.
C57BL/6J mice are refractory to many tumors http://jaxmice.jax.org/strain/000664.html Therefore, life extension is difficult to explain by anti-cancer effects of rapamycin.
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